Ocular Pain

  • Ocular pain, which is typically treated with topical steroid is highly prevalent in patients suffering from dry eye, uveitis, glaucoma, intraocular or orbital tumour, trigeminal neuralgias, ocular migraine etc.
  • Damage to the ocular surface (nociceptive pain) or to the somatosensory nervous system (neuropathic pain) due to the underlying pathogenesis of eye disease is the main cause of pain.
  • In an experimental model of neuropathic pain, MRGPR agonist OKYO-0201 showed promising results by significantly attenuating pain in mice. Our current focus is to further improve the potency of OKYO-0201 and develop novel formulations and delivery methods for the treatment of ocular pain.