Dry Eye Disease

  • Dry Eye is a multifactorial disease caused by underlying inflammation resulting in the lack of lubrication and moisture on the surface of the eye.
  • Symptoms of dry eye include constant discomfort and irritation accompanied by inflammation of the ocular surface, visual impairment and potential damage to the ocular surface.
  • Dry Eye affects over 35% of the population aged 50+, with women representing approximately two-thirds of those affected. Prevalence of dry eye is expected to increase substantially in the near future due to an aging population.
  • Dry eye syndrome represents a major economic burden to public healthcare, accounting for more than $50 billion to the US economy annually.

Chemerin - A novel approach for the treatment of Dry Eye Disease

Our therapeutic approach is to develop first-in-class drug candidates that target inflammatory pathways.

Using membrane-tethered ligand technology, we developed our lead candidate OK-101.  Thus far OK-101 has decreased dry eye symptoms in mice with no local irritation in rabbits.