Dry Eye Disease
- Dry Eye is a multifactorial disease caused by underlying inflammation resulting in the lack of lubrication and moisture on the surface of the eye.
- Symptoms of dry eye include constant discomfort and irritation accompanied by inflammation of the ocular surface, visual impairment and potential damage to the ocular surface.
- Dry Eye affects over 35% of the population aged 50+, with women representing approximately two-thirds of those affected. Prevalence of dry eye is expected to increase substantially in the near future due to an aging population.
- Dry eye syndrome represents a major economic burden to public healthcare, accounting for more than $50 billion to the US economy annually.
Chemerin - A novel approach for the treatment of Dry Eye Disease
Our therapeutic approach is to develop first-in-class drug candidates that target inflammatory pathways.
Using membrane-tethered ligand technology, we developed our lead candidate OK-101. Thus far OK-101 has decreased dry eye symptoms in mice with no local irritation in rabbits.