- Allergic conjunctivitis, often called ‘pink eye’ is an inflammation of conjunctiva, caused by an allergic reaction to pollen, mold, smoke, dust etc.
- Up to 40% of the global population suffers from allergic conjunctivitis, which is mostly treated with antihistamines and corticosteroids (2018 annual revenue in US was > $1 Bln). However, a significant number of patients do not respond to antihistamines that leads to overuse of corticosteroids in these patients.
- In an animal model, Chemerin receptor agonist OK-101 was effective in suppressing ocular inflammation by downregulating key inflammatory biomarkers CD4+ T cells. Additional studies are ongoing to determine the efficacy of OK-101 in diminishing ocular redness, the most common symptoms of allergic conjunctivitis.